In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug ...

Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis ...

Severe tricuspid regurgitation is associated with disabling symptoms and an increased risk of death. Data regarding outcomes after percutaneous transcatheter tricuspid-valve replacement are needed.

Although lead has been mined for 6000 years, lead processing skyrocketed in the 20th century. 1,8 A malleable and durable metal, lead was used to prevent fuel from burning too quickly and to ...

Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of ...

Dr. Patrick Malecha (Medicine): A 69-year-old man with a history of myocardial infarction, ischemic cardiomyopathy, and an implantable cardioverter–defibrillator (ICD) was evaluated because of ...

Supported by grants (U01DK072493 and UM1 DK072493, to Dr. Inge, and UM1 DK095710, to Drs. Jenkins and Xie) from the National Institutes of Health (NIH) and grants (UL1TR000077 and UL1TR000114 ...

On July 24, 2024, a 40-year-old woman (gravida 3, para 1, with a first-trimester pregnancy loss at 24 years of age) began to have fever, chills, generalized myalgia, and severe headache at 30 ...

In the article by Xie et al. (Aug. 8 issue) 1 regarding postacute sequelae of SARS-CoV-2 infection (PASC) in the pre-delta, delta, and omicron eras, the authors note that 71.89% of the decrease in ...

For patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction, current guidelines recommend routine clinical surveillance every 6 to 12 months. Data from ...

Artificial Intelligence (AI) has tremendous potential to advance clinical practice and the delivery of patient care. A new Review article series, “AI in Medicine,” explores the role of AI ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...